Beasley, Allen, Crow, Methvin, Portis & Miles, P.C.

The reports of health problems associated with hormone replacement therapy (HRT) keep coming. First, the Women’s Health Initiative identified women who took the combined estrogen-plus-progestin therapy were at a much greater risk of developing breast cancer. It later showed these women were at an increased risk of heart disease and other serious health problems. Now, an article published online in the Journal of Clinical Oncology suggests that women who took combined HRT are at an increased risk of lung cancer by as much as 50 percent.

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William T. Creasman was listed as the author of an article written by a freelance writer for the December 1998 Journal of Women’s Health. The title: “Is there an association between hormone replacement therapy and breast cancer?” The article points out that there is no “definitive evidence” that HRT is linked to breast cancer. But the dirty little secret behind that article in the medical journal is that Creasman didn’t actually write the article. It was authored by a writer for DesignWrite, a marketing firm that represented HRT-maker Wyeth, now owned by Pfizer. As the story was going to press, Wyeth was covering up evidence that proved otherwise. The drug company’s estrogen-plus-progestin HRT was, in fact, increasing a woman’s risk for breast cancer as well as heart disease and Alzheimer’s.

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A study involving nearly 58,000 women in France over a 12-year period suggests that hormone replacement therapy (HRT) may increase a woman’s risk of developing asthma after menopause. Researchers from the Gustave Roussy Institute in France and the Instituto Nacional de Salud Publica in Mexico published the findings in the British medical journal, Thorax. The study suggested that women who took HRT were 21 percent more likely to develop asthma than women who did not take HRT. The risk was even greater for women who took estrogen-only HRT compared to the combined estrogen-plus-progestin therapy, with the estrogen-only group at 54 percent greater risk of developing asthma compared to women who did not take HRT. This is the first long-term, large-scale study to suggest that estrogen-only HRT puts women at much greater risk of asthma than the combined therapy.

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There is plenty of bad press about hormone replacement therapy (HRT), a striking reversal of just a decade or two ago, when drug makers were touting the many benefits of HRT for menopausal women. Those drug makers spent millions of dollars developing advertising campaigns and paying doctors to write articles in medical journals claiming the pills that combined estrogen and progestin were the fountain of youth. They put an end to nasty menopause symptoms such as mood swings and hot flashes, and offered the added benefit of strengthening bones and protecting women against cancer and heart disease.

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Drug companies’ advertisements touting the benefits of hormone replacement therapy (HRT) sold Delores Ann Spann Whatley of Tyler, Texas on the idea that her mood swings and hot flashes could be wiped away with just a daily pill. The estrogen-and-progestin cocktail was touted as a miracle drug, able to squash menopause symptoms while warding against osteoporosis, heart disease and cancer. But the pharmaceutical companies soon realized that the HRT that was making them rich was actually making consumers sick. But instead of notifying the public and pulling their product, the drug companies attempted to cover up the mounting statistics and continued to advertise to women about the benefits of HRT.

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Women who reported new-onset breast tenderness following use of estrogen-plus-progestin hormone replacement therapy (HRT) were at a much greater risk of developing breast cancer than women on the same HRT who did not report tenderness in their breasts, according to a study by researchers from the David Geffen School of Medicine at the University of California – Los Angeles.

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The advertisements no longer blanket magazines or fill television screens, but the message cannot be deleted. Over the years, millions of women were told that estrogen loss during menopause could be dangerous to their health, contributing to problems such as osteoporosis, heart disease, colon cancer, Alzheimer’s disease, tooth loss and blindness. It could also cause uncomfortable symptoms such as hot flashes, vaginal dryness and mood swings. The ads said menopause was a nasty disease that could be eliminated by just taking a once-daily pill, a hormone replacement therapy (HRT) that would help women feel like women again.

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The message was heard loud and clear – powerful drug companies that make billions from products they know pose a significant risk of life-threatening health consequences to the people who take them, owe their victims. Big time.

This week, Pfizer, which recently acquired Wyeth, the makers of the hormone replacement therapies (HRT) Prempro and Premarin, were hit with more than $100 million in two punitive-damage awards from Philadelphia juries. The two plaintiffs, Connie Barton and Donna Kendall, claimed the drugs caused their breast cancer.

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A decrease in reported cases of breast cancer across the country linked to the decline of hormone replacement therapy (HRT) is more significant in affluent, urban areas, according to a study published in the journal BMC Medicine.

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Researchers in Ottawa, Canada are hoping to ease women’s fear of hormone replacement drugs by creating and testing synthetic hormones to combat aggravating symptoms of menopause, according to Canada.com. The research follows an earlier grant from the Canadian Breast Cancer Foundation to explore the re-engineering of estrogen estradiol, which is one of the components of the popular hormone replacement therapy (HRT) Premarin. The new grant, funded by a $267,000 research grant from the Canadian Breast Cancer Foundation, seeks to evaluate those compounds of synthesized molecules on the liver, cardiac and other types of cells. The goal is that it must relieve menopausal symptoms while not promoting breast or uterine cancer.

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